Connective tissue disease-associated lung disease in children

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Updated: Jun 24, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Andrew H Schapiro1,2, Cara E Morin3,4, Kathryn A Wikenheiser-Brokamp5,6,7,8

  • 1Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA. andrew.schapiro@cchmc.org.

Pediatric Radiology
|June 8, 2024
PubMed

Insights

Connective tissue diseases can impact children's lungs, causing serious illness. Recognizing specific radiologic-pathologic patterns on CT scans aids in early diagnosis and management of pediatric lung disease.

Area of Science:

  • Pediatric Rheumatology
  • Pulmonary Medicine
  • Pediatric Radiology

Background:

  • Connective tissue diseases (CTDs) are autoimmune disorders affecting multiple organ systems.
  • Lung involvement in pediatric CTDs significantly increases morbidity and mortality.
  • CTD-associated lung disease in children presents with distinct radiologic-pathologic patterns.

Purpose of the Study:

  • To review key clinical, histopathologic, and CT features of pediatric CTD-associated lung disease.
  • To emphasize radiologic-pathologic correlation for improved diagnostic accuracy.
  • To enhance the role of pediatric radiologists in managing these complex cases.

Main Methods:

  • Review of clinical presentations.
  • Analysis of histopathologic findings.
  • Correlation with computed tomography (CT) imaging patterns.

Main Results:

  • Specific radiologic-pathologic patterns are associated with particular CTDs in children.
  • Understanding these patterns aids in differential diagnosis.
  • CT is crucial for identifying and characterizing lung disease in pediatric CTD.

Conclusions:

  • Radiologic-pathologic correlation is essential for diagnosing CTD-associated lung disease in children.
  • Accurate CT interpretation empowers pediatric radiologists to improve patient care.
  • Early recognition of lung disease patterns facilitates timely intervention in pediatric CTD.

Keywords:
ChildrenComputed tomographyConnective tissue diseaseLungPathologyPediatric

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