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Updated: Jun 24, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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TMEM205 induces TAM/M2 polarization to promote cisplatin resistance in gastric cancer

Qiang Fu1,2,3, Xuwei Wu2,3,4, Zhongqi Lu1,2,3

  • 1Department of Ultrasound Medicine, Affiliated Hospital of Yanbian University, Yanji, 133000, Jilin, China.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
|June 8, 2024
PubMed

Insights

Transmembrane protein 205 (TMEM205) drives cisplatin resistance in gastric cancer (GC) by promoting cell growth and metastasis. Targeting TMEM205 could enhance chemotherapy effectiveness for GC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cisplatin (DDP) is a primary chemotherapy for gastric cancer (GC), but resistance limits its efficacy.
  • Transmembrane protein 205 (TMEM2005) is implicated in drug resistance in other cancers and overexpressed in GC.
  • The specific role of TMEM205 in cisplatin-resistant GC is not well understood.

Purpose of the Study:

  • To investigate the role of TMEM205 in cisplatin resistance in gastric cancer.
  • To explore the mechanisms by which TMEM205 influences GC progression and drug sensitivity.

Main Methods:

  • In vivo and in vitro experiments were utilized to assess TMEM205 function.
  • Analysis included cell proliferation, stemness, epithelial-mesenchymal transition (EMT), migration, and angiogenesis assays.
  • The Wnt/β-catenin signaling pathway and tumor-associated macrophages (TAMs) polarization were examined.

Main Results:

  • TMEM205 overexpression was found to promote gastric cancer cell proliferation, stemness, EMT, migration, and angiogenesis.
  • TMEM205 activates the Wnt/β-catenin signaling pathway.
  • TMEM205 induces M2 polarization of TAMs, contributing to GC progression.

Conclusions:

  • TMEM205 plays a significant role in promoting cisplatin resistance in gastric cancer.
  • TMEM205 enhances GC progression through Wnt/β-catenin signaling and M2 macrophage polarization.
  • TMEM205 represents a potential therapeutic target to overcome DDP resistance in GC.
Keywords:
Cisplatin resistanceGastric cancerTransmembrane protein 205Tumor-associated macrophagesWnt/β-catenin

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