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Hospital Healthcare Resource Utilization and Associated Hospital Costs of Patients With Lupus Nephritis in China: A

Xin He1, Xiaochen Zhu2, Zhiliu Tang1

  • 1Value Evidence and Outcomes, GSK, Shanghai, China.

Value in Health Regional Issues
|June 8, 2024
PubMed

Insights

Patients with lupus nephritis (LN) in China incur significantly higher healthcare resource utilization and costs than those with systemic lupus erythematosus (SLE). End-stage kidney disease (ESKD) further elevates this burden, underscoring the need for early LN management.

Area of Science:

  • Nephrology
  • Rheumatology
  • Health Economics

Background:

  • Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE).
  • Understanding healthcare resource utilization (HCRU) and costs associated with LN in China is crucial for resource allocation and patient management.
  • The impact of end-stage kidney disease (ESKD) on HCRU and costs in LN patients requires further investigation.

Purpose of the Study:

  • To assess and compare hospital HCRU and costs for patients with LN in China against a broader SLE cohort.
  • To explore the additional impact of ESKD on HCRU and costs among patients with LN.
  • To provide data supporting early diagnosis and management strategies for LN in China.

Main Methods:

  • Retrospective analysis of administrative claims data from China.
  • Identification of patients with SLE and LN using diagnosis codes and keywords.
  • Subcategorization of LN patients based on the presence of ESKD; analysis of all-cause and disease-specific HCRU and medical costs.

Main Results:

  • A total of 3645 SLE patients were included, with 404 (11%) diagnosed with LN; 142 (35%) of LN patients had ESKD.
  • Patients with LN exhibited significantly higher healthcare visits per patient per month (PPPM) (2.08) compared to the SLE cohort (0.92) (P < .0001).
  • Median all-cause costs PPPM were substantially greater for LN patients ($287.46) versus SLE patients ($113.09) (P < .0001); ESKD further increased these metrics.

Conclusions:

  • Chinese patients with LN demonstrate significantly higher HCRU and healthcare costs compared to the general SLE population.
  • The presence of ESKD exacerbates the HCRU and economic burden in patients with LN.
  • These findings highlight the critical need for early LN diagnosis and prompt management to alleviate the substantial economic impact.
Abstract

Keywords:
cost of illnessend-stage kidney diseasehealthcare resource utilizationlupus nephritismedical costssystemic lupus erythematosus

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