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Updated: Jun 24, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

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The role of pyroptosis in metabolism and metabolic disease

Zhuyuan Zheng1, Shaojie Yang1, Wanlin Dai2

  • 1Biliary Surgery (2nd General) Unit, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 8, 2024
PubMed

Insights

Pyroptosis, a cell death process, drives inflammation and metabolic diseases like diabetes and obesity. Targeting pyroptosis offers a new therapeutic strategy for these conditions.

Area of Science:

  • Cellular Biology
  • Immunology
  • Metabolic Disease Research

Background:

  • Pyroptosis is a lytic, pro-inflammatory programmed cell death pathway.
  • It involves gasdermin proteins forming membrane pores, releasing inflammatory cytokines like IL-1β and IL-18.
  • Both canonical (caspase-1) and noncanonical (caspase-4/5/11) pathways activate pyroptosis.

Purpose of the Study:

  • To review advancements in understanding pyroptosis's role in metabolic diseases.
  • To explore pyroptosis as a potential therapeutic target for metabolic dysfunction.

Main Methods:

  • Literature review of current research on pyroptosis and metabolic diseases.
  • Analysis of the interplay between metabolic pathways and pyroptosis induction.
  • Examination of pyroptosis modulation in type 2 diabetes mellitus, obesity, and metabolic (dysfunction) associated fatty liver disease.

Main Results:

  • Chronic inflammation, driven by pyroptosis, contributes to metabolic disease development.
  • Dysregulation of metabolic pathways can trigger pyroptosis.
  • Pyroptosis plays a significant role in the progression of major metabolic diseases.

Conclusions:

  • Pyroptosis is intricately linked to the pathogenesis of metabolic diseases.
  • Modulating pyroptosis presents a promising therapeutic avenue for treating metabolic conditions.
  • Further research into pyroptosis mechanisms could unlock novel treatment strategies.
Keywords:
DiabetesMetabolic associated fatty diseaseMetabolic diseaseMetabolismObesityPyroptosis

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