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Cuproptosis in cancers: Function and implications from bench to bedside.

Xin-Yi Huang1, Jia-Yang Shen1, Ke Huang1

  • 1School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, Hubei 434023, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 8, 2024
PubMed
Summary

Cuproptosis, a novel cell death pathway involving copper, is crucial in cancer development. This review explores cuproptosis mechanisms and copper-based therapies for various cancers, offering new drug development strategies.

Keywords:
Cancer therapyCopperCopper chelatorCopper ionophoreCuproptosis

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Area of Science:

  • Biochemistry
  • Oncology
  • Cell Biology

Background:

  • Copper is an essential micronutrient vital for biological processes.
  • Cuproptosis, a copper-dependent cell death, is newly identified and linked to cancer.
  • Understanding cuproptosis is key to cancer research.

Purpose of the Study:

  • To review the roles and mechanisms of cuproptosis in diverse cancer types.
  • To explore copper-related agents' effects on cancer progression and treatment.
  • To highlight potential therapeutic strategies targeting cuproptosis.

Main Methods:

  • Literature review summarizing current research on cuproptosis.
  • Analysis of studies on cuproptosis in colorectal, lung, gastric, breast, liver cancers, and melanoma.
  • Examination of preclinical and clinical trial data on copper-related agents.

Main Results:

  • Cuproptosis mechanisms vary across different cancer types.
  • Copper chelators and ionophores impact cancer cell proliferation, apoptosis, angiogenesis, immunity, and chemoresistance.
  • Evidence suggests copper-based agents show promise in cancer treatment.

Conclusions:

  • Cuproptosis plays a significant role in the development of various cancers.
  • Targeting cuproptosis with copper-related agents presents a promising anticancer drug development strategy.
  • Further research into cuproptosis mechanisms and therapies is warranted.