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Strategies for developing μ opioid receptor agonists with reduced adverse effects

Yan Yuan1, Ting Xu2, Yu Huang1

  • 1College of Life Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 611756, China.

Bioorganic Chemistry
|June 8, 2024
PubMed
Summary

Researchers are developing new opioid drugs targeting the mu opioid receptor (MOR) to improve pain relief while minimizing side effects. This review explores various strategies for designing safer MOR agonists for therapeutic use.

Keywords:
Gα subtypeNew low efficacy agonistsSmall moleculesStructure-activity relationshipThe design approachesµ opioid receptor(MOR) agonists

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