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[Therapeutic experiences with high-dose ARA-C and L-ASP]
Onkologie
|February 1, 1985
Summary
High-dose cytarabine (HD-ARA-C) therapy showed limited efficacy in acute leukemias, with one complete remission and partial responses in two patients. The treatment regimen resulted in considerable toxicity and early mortality in some cases.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Context:
- Adult patients with acute leukemias (ALL and AML) were treated.
- The Capizzi protocol using high-dose cytarabine (HD-ARA-C) was administered.
- A total of 8 cycles were planned for each patient.
Purpose:
- To evaluate the efficacy and toxicity of HD-ARA-C (Capizzi protocol) in acute leukemia.
- To assess treatment response in patients with Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML).
Summary:
- One patient achieved complete remission.
- Two patients demonstrated partial responses to the therapy.
- Two patients experienced early mortality after the first cycle, precluding evaluation.
- Significant toxicity was observed during the treatment course.
Impact:
- HD-ARA-C (Capizzi protocol) demonstrated limited efficacy in this small cohort of acute leukemia patients.
- Considerable toxicity and early treatment-related mortality highlight challenges with this regimen.
- Findings suggest a need for alternative or modified treatment strategies for acute leukemias.