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Related Concept Videos

Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...

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Related Experiment Video

Updated: May 27, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
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Pirfenidone improves voiding function by suppressing bladder fibrosis in underactive bladder rats.

Il-Gyu Ko1, Lakkyong Hwang2, Jun-Jang Jin2

  • 1Research Support Center, School of Medicine, Keimyung University, Deagu, 42601, South Korea.

European Journal of Pharmacology
|June 8, 2024
PubMed
Summary

Pirfenidone effectively treats bladder fibrosis and improves urinary function in a rat model of underactive bladder (UAB). This study suggests pirfenidone as a potential therapy for UAB, offering hope for patients with this condition.

Keywords:
Bladder fibrosisMajor pelvic ganglionPirfenidoneUnderactive bladderVoiding dysfunction

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Area of Science:

  • Urology
  • Pharmacology
  • Fibrosis Research

Background:

  • Underactive bladder (UAB) presents complex symptoms and limited treatment options, significantly impacting patient quality of life.
  • UAB is characterized by bladder wall hyperplasia, fibrosis, and reduced bladder compliance.
  • Pirfenidone, an established anti-fibrotic agent, shows promise for treating fibrotic conditions.

Purpose of the Study:

  • To evaluate the efficacy of pirfenidone in treating bladder fibrosis.
  • To investigate pirfenidone's effects on urinary function in a rat model of UAB.

Main Methods:

  • Underactive bladder (UAB) was induced in rats via crushing damage to major pelvic ganglion nerve bundles.
  • Pirfenidone was administered orally at doses of 100, 300, or 500 mg/kg every two days for 20 days.
  • Bladder weight, fibrosis-related factors, and urinary function were assessed post-treatment.

Main Results:

  • Pirfenidone treatment significantly improved urinary function in the UAB rat model.
  • The drug reduced bladder weight and suppressed the expression of fibrosis-related factors.
  • Pirfenidone demonstrated dose-dependent effects in ameliorating UAB symptoms.

Conclusions:

  • Pirfenidone effectively ameliorates bladder fibrosis and improves voiding function in a preclinical UAB model.
  • These findings suggest pirfenidone as a potential therapeutic agent for treating underactive bladder.
  • Further research into pirfenidone for UAB could lead to new treatment options for patients with incurable UAB.