Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery.

Area of Science:

• Infectious Diseases
• Critical Care Medicine
• Surgical Infections

Background:

• Intra-abdominal infections (IAIs) are a significant global cause of hospital-acquired morbidity and mortality.
• Effective management hinges on diagnostics, source control, and antimicrobial therapy.

Purpose of the Study:

• To outline the essential components for optimal management of intra-abdominal infections.
• To emphasize the necessity of a personalized approach in treating complicated IAIs.

Main Methods:

• Review of current clinical practices and guidelines for IAI management.
• Emphasis on integrating pharmacokinetic/pharmacodynamic principles and antimicrobial stewardship.
• Highlighting the importance of continuous patient assessment.

Main Results:

• Cornerstones of IAI management include diagnostics, source control, appropriate antimicrobial therapy, and hemodynamic support.
• Personalized assessment of infection extent, pathogens, resistance risk, and host factors is crucial.

Conclusions:

• Optimizing outcomes in complicated IAIs necessitates a tailored strategy based on comprehensive patient and infection evaluation.
• Continuous reassessment of clinical status and host factors is vital for effective IAI management.