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Heterogeneous micellar solubilization within lyotropic liquid crystals interfaces.

Eliezer Y Goldmünz1, Abraham Aserin1, M Francesca Ottaviani2

  • 1The Casali Center for Applied Chemistry, The Institute of Chemistry, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 9190401, Israel.

Journal of Colloid and Interface Science
|June 9, 2024
PubMed
Summary
This summary is machine-generated.

Sodium diclofenac (Na-DFC) in emulsions undergoes structural changes, forming hexagonal and lamellar phases. Despite these shifts, Na-DFC release remains consistent due to stable interfacial structures, enabling selective molecular loading.

Keywords:
Chaotropic effectElectron paramagnetic resonanceHeterogeneous solubilizationHiguchi release profileKosmotropic effectLyotropic liquid crystalsNuclear quadrupole resonanceSmall-angle X-ray diffractionSodium diclofenacSpin probes

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Area of Science:

  • Materials Science
  • Physical Chemistry
  • Colloid Science

Background:

  • Glycerol monooleate (GMO) based emulsions are widely studied for drug delivery.
  • Understanding the structural behavior of emulsions upon drug incorporation is crucial for controlled release.
  • Sodium diclofenac (Na-DFC) is a common non-steroidal anti-inflammatory drug.

Purpose of the Study:

  • To investigate the structural transformations in GMO-based emulsions upon sodium diclofenac (Na-DFC) incorporation.
  • To elucidate the relationship between structural changes and the release kinetics of Na-DFC.
  • To explore the potential of selective molecular interfacial loading for drug delivery.

Main Methods:

  • Small-angle X-ray diffraction (SAXD) to analyze mesophase structures.
  • Spin-probe electron paramagnetic resonance (EPR) to probe interfacial properties.
  • Nuclear quadrupole resonance (NQR) to assess molecular dynamics and anisotropy.
  • SAXD peak fittings and EPR spectral computations for quantitative analysis.

Main Results:

  • Na-DFC incorporation induced transitions from hexagonal to lamellar mesophases with increasing concentration.
  • Despite structural changes, the driving force for Na-DFC release remained constant.
  • Selective solubilization of Na-DFC occurred at the interface, evidenced by changes in polarity, microviscosity, and order parameters.
  • NQR analysis indicated heterogeneous structural transformations linked to Na-DFC solubilization.

Conclusions:

  • The solubilization and release of Na-DFC in GMO emulsions are heterogeneous processes driven by localized increases in micellar free energy.
  • The interfacial structure remains constant during Na-DFC release, ensuring a consistent release rate.
  • Selective molecular interfacial loading offers a promising strategy for advanced drug delivery systems.