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Related Experiment Video

Updated: Jun 24, 2025

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
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Risk Factors for Pediatric Intracranial Neoplasms in the Kids' Inpatient Database.

Anthony Price1,2, Sean O'Leary3,4, Hannah Parker3,4

  • 1John Sealy School of Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA, antprice@utmb.edu.

Pediatric Neurosurgery
|June 9, 2024
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Summary
This summary is machine-generated.

Pediatric brain cancer mortality is higher in females and Black patients compared to males and white patients. These disparities highlight the need for improved resource allocation in pediatric central nervous system (CNS) tumor care.

Keywords:
Cerebral neoplasiaCerebral neoplasmChildhood brain cancerKids’ Inpatient DatabasePediatric neoplasia

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Area of Science:

  • Pediatric Oncology
  • Neuro-oncology
  • Epidemiology

Background:

  • Central nervous system (CNS) tumors are the leading cause of cancer-related mortality in children and adolescents.
  • Previous research indicates racial disparities in intracranial cancer rates and other risk factors.
  • This study utilizes the 2019 Kids' Inpatient Database (KID) to investigate these disparities.

Purpose of the Study:

  • To analyze mortality rates and associated risk factors for pediatric brain and CNS tumors.
  • To identify potential disparities in care based on race, sex, and socioeconomic factors.
  • To provide data for improving resource allocation and care for pediatric CNS tumor patients.

Main Methods:

  • Analysis of 7,818 pediatric patients (<21 years) with malignant neoplasms of the brain, brainstem, and cerebral meninges from the 2019 Kids' Inpatient Database (KID).
  • Evaluation of modifiable risk factors (hospital region, insurance, city size, income, hospital type) and non-modifiable factors (race, sex).
  • Statistical analysis using χ2 test with Yates' continuity correction and Tukey's ANOVAs in Excel and GraphPad Prism 9.

Main Results:

  • Significant differences in mortality rates were observed between females (2.88%) and males (1.99%), and across racial groups: Black (4.17%), Hispanic (2.95%), Asian/Pacific Islander (3.86%), compared to White (1.68%).
  • Black patients exhibited significantly higher mortality across all races (p < 0.01).
  • No significant difference in mortality was found based on hospital type or insurance status after accounting for race. Significant racial differences were noted in length of stay and charges.

Conclusions:

  • Findings confirm that gender and race are significant factors influencing mortality in pediatric intracranial neoplasms.
  • The study identifies significant disparities but does not pinpoint root causes.
  • Results emphasize the need for improved national resource allocation to enhance care for pediatric CNS tumor patients.