Funding and conclusions of network meta-analyses on targeted therapies in inflammatory diseases: an overview
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View abstract on PubMed
Summary
This summary is machine-generated.Industry funding did not bias network meta-analyses conclusions, but nearly all favored their own drugs. Clinical Practice Guidelines often used these industry-funded analyses.
Area Of Science
- Pharmacology
- Medical Research Methodology
- Evidence-Based Medicine
Background
- Network meta-analyses (NMAs) synthesize evidence from multiple randomized controlled trials.
- Clinical Practice Guidelines (CPGs) inform healthcare decisions.
- The influence of industry funding on NMAs and their subsequent use in CPGs requires investigation.
Purpose Of The Study
- To examine the association between industry funding and the conclusions of NMAs.
- To assess the utilization of NMAs, particularly industry-funded ones, within CPGs.
Main Methods
- An overview of NMAs and CPGs was conducted.
- Searches were performed in PubMed/MEDLINE, Epistemonikos, and guideline databases up to February 2023.
- Included NMAs evaluated targeted therapies in immune-mediated inflammatory diseases; CPGs were from the last five years.
Main Results
- Of 216 NMAs, 31% were industry-funded. Industry-funded NMAs were more likely to cite one treatment as best (44% vs. 26%).
- Unsupported conclusions were found in 58% of industry-funded NMAs versus 46% of non-industry-funded NMAs.
- All industry-funded NMAs favoring one treatment promoted their sponsored drug. 39% of CPGs cited industry-funded NMAs.
Conclusions
- No significant evidence suggests industry funding biases NMA conclusions towards unsupported results or single-treatment recommendations.
- However, industry-funded NMAs predominantly favored their own treatments.
- A substantial proportion of CPGs incorporated industry-funded NMAs into their recommendations.
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