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Updated: Jun 29, 2026

An Orthotopic Model of Murine Bladder Cancer
Published on: February 6, 2011
Urothelial carcinoma in a mule
A C Valim1, A M D Costa1, J G Quitzan2
1Department of Veterinary Clinical Science, School of Veterinary Medicine and Animal Science, São Paulo State University (Unesp), Rua Prof. Dr. Walter Mauricio Correa, s/n, Botucatu, SP 18618-681, Brazil.
This study details a rare urothelial carcinoma (UC) case in a mule. Treatment involved chemotherapy and surgical excision, leading to a full recovery with no recurrence observed 18 months later.
Area of Science:
- Veterinary Medicine
- Oncology
Background:
- Equine bladder neoplasms are uncommon, presenting diagnostic challenges.
- Urothelial carcinoma (UC) is a rare form of bladder cancer in equids.
Observation:
- A 20-year-old female mule presented with hematuria and anemia.
- Cystoscopy revealed a pedunculated mass in the dorsal bladder region.
- Histopathology confirmed urothelial carcinoma.
Findings:
- Initial treatment involved cystoscopic fluorouracil injections.
- Surgical excision via cystoscopy was performed due to tumor characteristics.
- The mule recovered fully, with normalized hematocrit and urine appearance.
Implications:
- This case highlights UC as a differential diagnosis for hematuria and anemia in equids.
- Successful treatment involved a combination of chemotherapy and surgical excision.
- Long-term remission was achieved, suggesting effective therapeutic strategies for equine bladder cancer.
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Published on: October 30, 2013
09:28Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
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