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Updated: Jun 24, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
Urinary D-amino acid profiles in cats with chronic kidney disease
Ren Kimura1, Reeko Ueda2, Hisashi Tsujimura1
1Analytical Science Research Laboratories, Kao Corporation, Tokyo, Japan.
Abstract:
Chronic kidney disease (CKD) is highly prevalent in domestic cats. This study aimed to compare urinary D-amino acid levels between control and CKD-afflicted cats as a novel noninvasive method for assessing CKD. Cats were divided into control and CKD stage II groups in accordance with the International Renal Interest Society guidelines. The urinary DL-amino acid levels of the cats were analyzed using chiral tandem liquid chromatography-tandem mass spectrometry, and their medical records were investigated. The CKD group had considerably lower urinary D-amino acid concentrations and enantiomeric ratios than the control group. The total urinary D-amino acid contents significantly correlated with blood parameters (creatinine and urea nitrogen). These findings may contribute towards the detection of CKD stage II in domestic cats.
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