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Updated: May 3, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Association Between Periodontitis and Preeclampsia: A Bidirectional Mendelian Randomisation Analysis
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
International Dental Journal
|June 9, 2024
Summary
This study found no evidence of a causal link between periodontitis (PD) and preeclampsia (PE). Genetic analysis indicates that neither condition increases the risk of developing the other.
Area of Science:
- Genetics
- Epidemiology
- Obstetrics
Background:
- The relationship between periodontitis (PD) and preeclampsia (PE) is debated, with inconsistent findings regarding causality.
- Bidirectionality of any potential causal link between PD and PE remains unclear.
Purpose of the Study:
- To investigate the potential bidirectional causal relationship between periodontitis and preeclampsia using Mendelian randomization.
- To clarify whether periodontitis influences the risk of preeclampsia or vice versa.
Main Methods:
- Mendelian randomization (MR) analysis utilizing genetic variants from genome-wide association studies (GWAS) for periodontitis and preeclampsia.
- Inverse variance weighting (IVW) as the primary method, with MR-Egger, weighted median, and MR-PRESSO for sensitivity and pleiotropy analyses.
Main Results:
- No evidence of a causal effect of periodontitis (including chronic and aggressive subtypes) on preeclampsia.
- No evidence of a causal effect of preeclampsia on periodontitis was detected in the reverse MR analysis.
- Sensitivity and pleiotropy analyses confirmed the robustness of the primary findings.
Conclusions:
- Mendelian randomization analysis suggests no bidirectional causal relationship between periodontitis and preeclampsia.
- Periodontitis and preeclampsia do not appear to causally influence each other's risk based on genetic evidence.
- Clinical attention for periodontitis to prevent preeclampsia development may not be genetically warranted.
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