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Related Experiment Video

Updated: Jun 24, 2025

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

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Published on: October 20, 2023

Moderate aortic stenosis: Navigating the uncharted.

Maria Vittoria Caprio^1,2, Federica De Donno^1,2, Giandomenico Bisaccia¹

¹Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.

Echocardiography (Mount Kisco, N.Y.)

|June 10, 2024

Summary

Aortic stenosis (AS) is common, and diagnosing moderate cases is challenging. Multimodality imaging may improve intervention timing for better outcomes in AS patients.

Keywords:

clinical outcomes early aortic valve replacement moderate aortic stenosis multi‐modality cardiovascular imaging risk stratification

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A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

Area of Science:

Cardiology
Cardiovascular Imaging
Valvular Heart Disease

Background:

Aortic stenosis (AS) is the most frequent valvular heart disease in developed nations.
It causes progressive aortic valve narrowing, leading to heart failure and sudden death.
Moderate AS presents diagnostic and therapeutic challenges due to measurement discrepancies.

Purpose of the Study:

To review clinical challenges and evolving perspectives in moderate aortic stenosis.
To highlight the role of noninvasive multimodality imaging in AS management.
To emphasize the need for improved decision-making frameworks for moderate AS.

Main Methods:

Narrative review of clinical challenges and evolving perspectives in moderate AS.
Discussion of transthoracic echocardiography and ancillary noninvasive diagnostic modalities.
Exploration of noninvasive multimodality imaging approaches (echocardiography, CMR, CT, nuclear techniques).

Main Results:

Discrepancies in aortic valve area and pressure gradient measurements complicate moderate AS diagnosis.
Accurate AS severity grading, especially in low-gradient phenotypes, is crucial.
Current guidelines focus on severe AS, potentially underestimating risks in moderate stages.

Conclusions:

Noninvasive multimodality imaging offers insights into cardiac remodeling and precise intervention timing for moderate AS.
Further research, including randomized trials, is needed to establish benefits of preemptive aortic valve replacement in moderate AS.
Biomarker-directed management strategies are essential for optimizing outcomes in moderate AS.