Metal-organic framework (MOF)-based materials for pyroptosis-mediated cancer therapy

Area of Science:

• Biomedical Engineering
• Materials Science
• Oncology

Background:

• Pyroptosis is a promising strategy for modulating tumor immune microenvironments in anticancer therapy.
• Current pyroptosis inducers face challenges including drug resistance, off-targeting, and adverse effects, limiting their therapeutic efficacy.
• Metal-organic frameworks (MOFs) possess unique structures and facile synthesis/functionalization, showing significant potential in anticancer applications.

Purpose of the Study:

• To review the latest advances in MOF-based materials designed to evoke pyroptosis.
• To provide a comprehensive overview of different MOF types utilized for pyroptosis-mediated cancer therapy.
• To discuss the current challenges and future prospects of MOF-based pyroptosis inducers.

Main Methods:

• Literature review of recent studies on MOFs for pyroptosis induction.
• Categorization and analysis of various MOF structures and their mechanisms in pyroptosis.
• Discussion of MOF-based drug delivery systems for pyroptosis inducers.

Main Results:

• MOFs can be designed with inherent anticancer properties and serve as effective carriers for pyroptosis-inducing drugs.
• The tunable nature of MOFs allows for tailored delivery and enhanced therapeutic outcomes.
• MOF-based strategies show promise in overcoming limitations associated with conventional pyroptosis inducers.

Conclusions:

• MOF-based materials represent a significant advancement in developing effective pyroptosis inducers for cancer therapy.
• Further research into MOF design and application is crucial to address existing challenges and unlock their full therapeutic potential.
• MOFs offer a versatile platform for next-generation pyroptosis-mediated cancer treatments.