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Related Concept Videos

Hallucinogens and Psychedelics01:27

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Related Experiment Video

Updated: Jun 24, 2025

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Time-resolved coupling between connectome harmonics and subjective experience under the psychedelic DMT.

Jakub Vohryzek1,2, Andrea I Luppi1,3,4,5, Selen Atasoy1,6

  • 1Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, United Kingdom.

Biorxiv : the Preprint Server for Biology
|June 10, 2024
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Summary

Psychedelic drugs like DMT alter brain connectivity patterns, similar to psilocybin and LSD. This research links these brain changes, specifically connectome harmonics, to the intensity of subjective experiences during drug use.

Keywords:
connectome harmonicsfMRIpsychedelics

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Computational Neuroscience

Background:

  • Understanding the brain's structural and functional networks is key to deciphering subjective experiences.
  • Psychedelics modulate neurotransmitter systems, offering insights into perception, cognition, and consciousness.

Purpose of the Study:

  • To investigate the effects of N,N-Dimethyltryptamine (DMT) on brain function through the lens of connectome harmonic decomposition.
  • To determine if DMT alters the brain's functional repertoire in a manner consistent with other known psychedelics.
  • To explore the relationship between changes in connectome harmonics and the intensity of subjective psychedelic experiences.

Main Methods:

  • Utilized connectome harmonic decomposition, a framework analyzing brain function's dependence on structural connectome organization.
  • Analyzed brain activity patterns under DMT and compared the resulting connectome harmonic repertoire with data from psilocybin, LSD, and ketamine.
  • Measured repertoire entropy and energy spectrum difference of connectome harmonics over time.

Main Results:

  • The connectome harmonic repertoire under DMT showed significant reshaping, mirroring effects observed with psilocybin, LSD, and ketamine.
  • Repertoire entropy of connectome harmonics increased under DMT, consistent with other psychedelic compounds.
  • Measures of energy spectrum difference and repertoire entropy correlated with the intensity of subjective experiences in a time-resolved manner.

Conclusions:

  • DMT, like other psychedelics, alters the brain's functional organization across its structural connectome.
  • The study establishes a direct, time-resolved link between brain network dynamics (connectome harmonics) and the intensity of subjective psychedelic states.
  • Connectome harmonic decomposition provides a valuable tool for quantifying the neural correlates of psychedelic-induced experiences.