Related Experiment Video
Updated: Jun 24, 2025
Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
Published on: August 10, 2018
Unveiling a Rare Case: Madras Motor Neuron Disease in an 18-Year-Old Patient
Keyur Saboo1, Sourya Acharya1, Sunil Kumar1
1Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Abstract:
Madras motor neuron disease (MMND) is a rare childhood or juvenile motor neuron disease. Herein, we present a unique case of MMND in an 18-year-old patient, which challenges the conventional understanding of the disease's onset and progression. The patient, a previously healthy adolescent, presented with insidious onset and gradually progressive weakness of all four limbs, wasting, tongue fasciculation, and bilateral sensorineural hearing loss. Neurological examination revealed signs consistent with lower motor neuron involvement. Electromyography (EMG) and nerve conduction studies (NCS) supported the diagnosis of MMND. The patient's clinical course exhibited rapid deterioration, leading to significant functional impairment within a short timeframe. Treatment modalities, including supportive care and symptomatic management, were implemented; however, disease progression remained relentless. This case highlights the significance of considering MMND in the differential diagnosis of motor neuron diseases, even in young individuals. It highlights the importance of conducting more studies to comprehend the underlying mechanisms and consider potential therapeutic strategies for this uncommon ailment.
Insights
This study details a unique case of Madras motor neuron disease (MMND) in an 18-year-old, challenging typical disease onset. The rare condition presented with rapid progression and severe motor neuron symptoms in a young adult.
Area of Science:
- Neurology
- Rare Diseases
- Neurodegenerative Disorders
Background:
- Madras motor neuron disease (MMND) is typically a childhood or juvenile-onset motor neuron disease.
- Understanding of MMND's typical presentation and progression is limited due to its rarity.
Observation:
- A unique case of MMND is presented in an 18-year-old patient, deviating from the usual age of onset.
- The patient exhibited insidious onset of progressive quadriparesis, muscle wasting, tongue fasciculation, and sensorineural hearing loss.
- Clinical course showed rapid deterioration and significant functional impairment despite supportive and symptomatic management.
Findings:
- Neurological examination confirmed lower motor neuron involvement.
- Electromyography (EMG) and nerve conduction studies (NCS) supported the diagnosis of MMND.
- The disease progression was relentless, underscoring the aggressive nature of this atypical presentation.
Implications:
- This case broadens the differential diagnosis for motor neuron diseases in adolescents and young adults.
- Highlights the need for further research into MMND's underlying mechanisms.
- Emphasizes the importance of exploring potential therapeutic strategies for this uncommon ailment.
More Related Videos
06:35In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
Published on: June 15, 2018
08:16Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
Published on: March 4, 2014
Related Concept Videos
01:21Satellite Stem Cells and Muscular Dystrophy
01:20Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
01:15Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...