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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

113
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
113
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

74
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
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Abdominal Regions and Quadrants01:19

Abdominal Regions and Quadrants

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To promote clear communication, for instance, about the location of a patient's abdominal pain or a suspicious mass, anatomists and clinicians typically use imaginary lines to categorize the abdominopelvic cavity into either four quadrants or nine regions to identify organs in the cavity.
The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersects at the patient's umbilicus (navel). The four...
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Related Experiment Video

Updated: Jun 24, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Sex Differences in Appendicitis: A Systematic Review.

Theofanis F Kollias1, Connor P Gallagher2, Abdulahad Albaashiki2

  • 1Microbiology, Immunology, and Pharmacology, St. George's University School of Medicine, St. George's, GRD.

Cureus
|June 10, 2024
PubMed
Summary
This summary is machine-generated.

Males are more prone to appendicitis and perforation. Diagnostic tools show sex-based accuracy differences, and while males undergo open surgery more, females experience higher complication rates post-appendectomy.

Keywords:
antibiotic therapyappendectomyappendicitisdiagnosing appendicitissex differences

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Area of Science:

  • Gastroenterology and Surgical Research
  • Sex Differences in Health Outcomes

Background:

  • Appendicitis is a common gastrointestinal condition with noted sex-based disparities.
  • Existing research indicates males have a higher incidence and risk of perforated appendicitis.

Purpose of the Study:

  • To systematically review and evaluate sex differences in appendicitis across incidence, risk factors, symptoms, diagnosis, treatment, and outcomes.
  • To identify how these sex differences impact clinical management and patient prognosis.

Main Methods:

  • Systematic review adhering to PRISMA guidelines.
  • Searched PubMed, ScienceDirect, and ProQuest databases for relevant studies.
  • Analyzed 28 selected publications from an initial pool of 21,121 articles.

Main Results:

  • Males exhibit a significantly higher incidence rate and risk of perforated appendicitis.
  • Diagnostic scores like the Pediatric Appendicitis Score (PAS) and Ohmann score show differential accuracy between sexes.
  • Females experienced delayed CT scans but more extensive imaging, while males underwent more open appendectomies; females had higher complication rates.

Conclusions:

  • Significant sex differences exist in appendicitis incidence, diagnosis, treatment, and outcomes.
  • Further research is needed to understand predictors of postoperative outcomes and to develop sex-specific prevention strategies.