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Updated: Jun 24, 2025

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
Published on: September 30, 2021
Hemophilia Gene Therapy: Another Blessing or Another Curse?
1Medical Director of The John Bouhasin Center for Children with Bleeding Disorders and Adjunct Professor, Department of Pediatrics, Division of Pediatric Hematology/Oncology, Saint Louis University School of Medicine and SSM Health Cardinal Glennon Children's Medical Center, St. Louis, Missouri.
Abstract:
Medical therapies for hemophilia patients over the past 60 years have included several blessings and a curse. The long-sought cure with gene therapy may have finally arrived. Unfortunately, preclinical animal models are now raising concerns for genotoxicity with gene therapy. Although no cancers have been detected in humans, it may be a few decades before we know if gene therapy for hemophilia is another blessing, or another curse.
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