Age-associated declined function of endothelial progenitor cells and its correlation with plasma IL-18 or IL-23
Yuanting Zhu1,2,3, Guoyi Cai1,3, Luyang Lin1,3
1Division of Emergency Medicine, Department of Emergency Intensive Care Unit, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Insights
Aging impairs endothelial progenitor cell (EPC) function in ST-segment elevation myocardial infarction (STEMI) patients, linked to increased inflammatory cytokines IL-18 and IL-23. This suggests new therapeutic targets for elderly STEMI patients.
Area of Science:
- Cardiology
- Gerontology
- Immunology
Background:
- ST-segment elevation myocardial infarction (STEMI) disproportionately affects the elderly, who experience reduced endothelial progenitor cell (EPC) capacity.
- The specific impact of aging on EPC function in STEMI patients remains incompletely understood.
Purpose of the Study:
- To investigate the influence of aging on EPC function in STEMI patients.
- To explore the relationship between age, EPC function, inflammatory cytokines (IL-18, IL-23), and clinical risk scores (TIMI, GRACE).
Main Methods:
- Enrolled younger and older STEMI patients.
- Assessed Thrombolysis in Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) scores.
- Measured EPC migration, proliferation, adhesion, and plasma IL-18/IL-23 concentrations.
- Analyzed correlations between age, EPC function, cytokines, and clinical scores.
Main Results:
- Older STEMI patients exhibited higher GRACE/TIMI scores and diminished EPC function compared to younger patients.
- EPC function was inversely correlated with GRACE/TIMI scores.
- Plasma IL-18 and IL-23 levels were elevated in older patients, negatively correlating with EPC function and positively with GRACE/TIMI scores.
- Age correlated positively with IL-18/IL-23 and GRACE/TIMI scores, but negatively with EPC function.
Conclusions:
- Aging impairs EPC function in STEMI, potentially mediated by inflammatory cytokines like IL-18 and IL-23.
- This study provides insights into the mechanisms underlying aging in STEMI and identifies potential therapeutic targets.
Background:
ST-segment elevation myocardial infarction (STEMI) persists to be prevalent in the elderly with a dismal prognosis. The capacity of endothelial progenitor cells (EPCs) is reduced with aging. Nevertheless, the influence of aging on the functionality of EPCs in STEMI is not fully understood.
Method:
This study enrolled 20 younger STEMI patients and 21 older STEMI patients. We assessed the Thrombolysis in Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events Risk (GRACE) scores in two groups. Then, we detected EPC migration, proliferation, adhesion, and plasma interleukin (IL)-18 and IL-23 concentrations in two groups. In addition, we analyzed the interconnection between age, EPC function, plasma IL-18 and IL-23 concentrations, and GRACE or TIMI scores in STEMI patients.
Result:
GRACE and TIMI scores in older STEMI patients were higher than in younger STEMI patients, whereas EPC function declined. GRACE and TIMI scores were found to have an inverse relationship with the EPC function. In older STEMI patients, plasma concentrations of IL-18 and IL-23 increased. Plasma IL-18 and IL-23 concentrations were adversely connected to EPC capacity and positively related to GRACE and TIMI scores. Moreover, age was positively correlated with plasma IL-18 or IL-23 concentrations, as well as GRACE or TIMI scores. However, age was adversely correlated with EPC function.
Conclusion:
In patients with STEMI, aging results in declined EPC function, which may be associated with inflammatory cytokines. The current investigation may offer new perception about mechanism and therapeutic targets of aging STEMI.
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