Epidemiological Study on Case Definition of Methicillin-Resistant Staphylococcus aureus Enteritis

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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

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Yusuke Yagi1,2, Akito Doke1,3, Saya Iwame1,3

  • 1Department of Infection Prevention and Control, Kochi Medical School Hospital, Nankoku, Kochi, Japan.

Infection and Drug Resistance
|June 10, 2024
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) enteritis diagnosis can be improved by identifying key risk factors. Elevated white blood cell counts, high MRSA stool culture counts, and recent meropenem use are significant indicators.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) enteritis arises from abnormal intestinal MRSA growth post-antibiotic use.
  • Current diagnostic criteria for MRSA enteritis lack clarity, necessitating epidemiological studies.
  • Distinguishing MRSA enteritis from asymptomatic MRSA carriage is clinically important.

Purpose of the Study:

  • To define diagnostic criteria for MRSA enteritis through epidemiological investigation.
  • To identify risk factors associated with the development of MRSA enteritis.

Main Methods:

  • A cohort of patients with positive MRSA stool cultures was analyzed.
  • MRSA enteritis was defined by response to vancomycin, severe diarrhea (Bristol Stool Scale ≥ 5), and high stool frequency (≥ 3/day).
  • Multivariate logistic regression identified risk factors for MRSA enteritis.

Main Results:

  • 18 patients (25.4%) were classified with MRSA enteritis (Group A) and 53 (74.6%) as MRSA carriers (Group B).
  • Risk factors for MRSA enteritis included elevated white blood cell count (> 10000/µL), high MRSA stool culture counts (≥ 2+), and recent meropenem administration (within 1 month).
  • Odds ratios for these factors ranged from 5.50 to 8.91.

Conclusions:

  • The proposed case definitions for MRSA enteritis may serve as valuable diagnostic criteria.
  • Identifying these risk factors can aid in the accurate diagnosis of MRSA enteritis.
Keywords:
MRSA counts in stool culturesMRSA enteritisdiagnostic criteriameropenemwhite blood cell

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