Pepsinogen isozymes in Borrmann IV type gastric carcinoma

Immunoperoxidase staining for human group I and group II pepsinogens (PG I, PG II) was performed on stomachs including surgically removed 42 Borrmann IV type gastric carcinomas (B-IV), 6 duodenal ulcers and 6 autopsy cases of traffic accident. Besides, 8 surgical cases of B-IV were examined by polyacrylamide gel electrophoresis (PAGE). All 8 cases examined by PAGE showed positive finding for at least one pepsinogen isozyme. In male, 19/19 were positive while in female 21/23 were positive for PG I and/or PG II by the immuno-peroxidase method.