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Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

257
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
257

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Related Experiment Video

Updated: Jun 24, 2025

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
11:12

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Published on: July 16, 2014

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Deep Brain Stimulation for Parkinson's Disease.

Atsushi Umemura

    Juntendo Iji Zasshi = Juntendo Medical Journal
    |June 10, 2024
    PubMed
    Summary
    This summary is machine-generated.

    Deep brain stimulation (DBS) offers an adjustable and reversible treatment for Parkinson's disease (PD) when medications fail. This surgical option, targeting areas like the subthalamic nucleus (STN), effectively manages motor symptoms and complications.

    Keywords:
    Parkinson's diseasedeep brain stimulationsubthalamic nucleus

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    Area of Science:

    • Neurology
    • Neurosurgery
    • Biomedical Engineering

    Background:

    • Parkinson's disease (PD) has a long history of surgical interventions.
    • Deep brain stimulation (DBS) is a key treatment for medically refractory PD.
    • DBS involves implanting devices to deliver electrical stimulation to specific brain regions, modulating neurological function.

    Purpose of the Study:

    • To provide a comprehensive review of Deep Brain Stimulation (DBS) for Parkinson's disease (PD).
    • To cover the history, mechanism, indications, outcomes, complications, and future technologies of DBS for PD.

    Main Methods:

    • Review of historical and current literature on DBS for PD.
    • Analysis of surgical procedures and targeting techniques, particularly the subthalamic nucleus (STN).
    • Discussion of clinical outcomes, patient indications, and potential complications.

    Main Results:

    • DBS is an effective, adjustable, and reversible treatment for PD, especially for motor complications like fluctuations and dyskinesia.
    • The subthalamic nucleus (STN) is a common and effective target for DBS in PD patients.
    • A combination of medical therapy and DBS provides long-term motor symptom relief for PD.

    Conclusions:

    • DBS is a significant advancement in managing Parkinson's disease, offering substantial relief from motor symptoms.
    • While not a cure, DBS combined with medication offers a long-term management strategy for PD.
    • Ongoing technological advancements continue to refine DBS therapy for Parkinson's disease.