Treatment of sebaceous carcinoma with Mohs micrographic surgery versus wide local excision: a systematic review
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Summary
This summary is machine-generated.Mohs micrographic surgery (MMS) shows lower recurrence rates for sebaceous carcinoma (SC) compared to wide local excision (WLE). MMS is a superior option for managing SC, reducing local, regional, and distant recurrence risks.
Area Of Science
- Dermatology
- Surgical Oncology
- Ophthalmology
Background
- Sebaceous carcinoma (SC) is a rare neoplasm with potential for recurrence and morbidity.
- Established management guidelines for SC are lacking.
- Traditional treatment involves wide local excision (WLE), but Mohs micrographic surgery (MMS) offers advantages.
Purpose Of The Study
- To systematically review and compare surgical modalities for sebaceous carcinoma management.
- To evaluate recurrence rates associated with WLE versus MMS for SC.
Main Methods
- Systematic literature review of MEDLINE, Embase, Cochrane, and Scopus databases.
- Inclusion of 70 studies (retrospective cohort, case series, case reports) investigating WLE or MMS for SC.
- Subgroup analysis of recurrence rates based on surgical technique.
Main Results
- MMS demonstrated significantly lower local, regional, and distant recurrence rates compared to WLE.
- Local recurrence rates: WLE 23.4% vs. MMS 6.8%.
- Regional recurrence rates: WLE 13.3% vs. MMS 4.3%.
- Distant recurrence rates: WLE 11.0% vs. MMS 4.6%.
Conclusions
- Mohs micrographic surgery (MMS) offers superior outcomes in managing sebaceous carcinoma by reducing recurrence.
- MMS is a recommended surgical option for SC due to its effectiveness in preventing local, regional, and distant disease spread.
- Further research is needed to evaluate disease-specific survival and address study limitations like heterogeneity and variable follow-up.
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