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Updated: Jun 24, 2025

Author Spotlight: Utilizing Venoplasty Balloon Model in Rodents to Simulate Surgical Interventions for Deep Veins
05:44

Author Spotlight: Utilizing Venoplasty Balloon Model in Rodents to Simulate Surgical Interventions for Deep Veins

Published on: May 24, 2024

617

Rodent Inferior Vena Cava Venoplasty Balloon Model.

Oscar Moreno1, Catherine E Luke2, Amber Clay2

  • 1Section of Vascular Surgery, Department of Surgery, University of Michigan; oscarmo@med.umich.edu.

Journal of Visualized Experiments : Jove
|June 10, 2024
PubMed
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A new rodent model for balloon venoplasty enables testing of treatments for deep vein stenosis. This model allows detailed analysis of vein wall and thrombus changes, aiding the development of therapies for chronic venous obstruction.

Area of Science:

  • Vascular Surgery
  • Medical Device Development
  • Animal Models

Background:

  • Deep vein stenosis and occlusion are clinical challenges often resulting from trauma, congenital issues, deep vein thrombosis (DVT), or stenting.
  • Chronic venous obstruction involves thrombosis and fibrosis, with no current direct treatments targeting these pathological processes.
  • A validated in vivo model is crucial for evaluating novel interventions for venous stenosis.

Purpose of the Study:

  • To introduce and validate a rodent survival inferior vena cava (IVC) venoplasty balloon model (VBM).
  • To enable the study of balloon venoplasty in both non-thrombotic and post-thrombotic conditions.
  • To provide a platform for quantifying the effects of coated and uncoated venoplasty balloons.

Main Methods:

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Last Updated: Jun 24, 2025

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617
Murine Model of Central Venous Stenosis using Aortocaval Fistula with an Outflow Stenosis
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  • Development of a rodent survival IVC venoplasty balloon model (VBM).
  • Application of balloon venoplasty in non-thrombotic and post-thrombotic IVC conditions.
  • Utilizing various assays including RT-PCR, western blot, ELISA, zymography, cellular analysis, and histology to assess local and systemic effects.

    • Main Results:

    • The VBM is reproducible and replicates human surgical interventions.
    • The model allows for the identification of local vein wall and thrombus protein changes.
    • Multiple analyses can be performed on the same sample, reducing animal usage.

    Conclusions:

    • The rodent VBM is a reliable tool for studying balloon venoplasty in venous stenosis and obstruction.
    • This model facilitates the investigation of novel therapeutic strategies for chronic deep venous diseases.
    • The VBM supports comprehensive analysis, improving research efficiency and animal welfare.