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Updated: Jun 24, 2025

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
Lung Cancer Screening in the US, 2022
Priti Bandi1, Jessica Star1, Kilan Ashad-Bishop1
1Surveillance & Health Equity Science, American Cancer Society, Atlanta, Georgia.
Annual lung cancer screening (LCS) is recommended for high-risk individuals, but up-to-date screening rates remain low nationwide. Disparities in LCS prevalence are significant across states and linked to healthcare access.
Area of Science:
- Public Health
- Preventive Medicine
- Epidemiology
Background:
- The US Preventive Services Task Force (USPSTF) recommends annual lung cancer screening (LCS) using low-dose computed tomography for individuals aged 50-80 years with a significant smoking history.
- Early detection through LCS aims to reduce lung cancer mortality, but representative data on screening prevalence at the state level are limited.
Purpose of the Study:
- To estimate the current prevalence of up-to-date (UTD) lung cancer screening nationwide and across all US states.
- To identify disparities in UTD-LCS prevalence based on demographics, health status, and geographic location.
Main Methods:
- This cross-sectional study utilized data from the 2022 Behavioral Risk Factor Surveillance System (BRFSS), a nationwide, state-representative survey.
- The analysis included 25,958 respondents aged 50-79 years who met the 2021 USPSTF eligibility criteria for LCS.
Main Results:
- The overall prevalence of UTD-LCS was 18.1%, with significant variation across states (9.7%-31.0%), notably lower in southern states with high lung cancer burden.
- UTD-LCS prevalence increased with age and number of comorbidities. Individuals without insurance or a usual source of care had lower screening rates.
- State Medicaid expansion and higher screening capacity were associated with increased UTD-LCS prevalence.
Conclusions:
- The prevalence of up-to-date lung cancer screening remains low nationally, with substantial geographic and healthcare access disparities.
- State-level initiatives focusing on expanding healthcare access and screening facilities are crucial for improving LCS rates and reducing health inequities.
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