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Updated: Jun 24, 2025
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Global biomarker trends in triple-negative breast cancer research: a bibliometric analysis
Xingxin Wang1, Xuhao Li1, Tiantian Dong2
1College of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, China.
Triple-negative breast cancer (TNBC) biomarker research is rapidly expanding, focusing on immune, microenvironment, and genetic markers. Enhanced collaboration is crucial for advancing TNBC diagnosis and treatment.
Area of Science:
- Oncology
- Biomarker Research
- Bioinformatics
Background:
- Triple-negative breast cancer (TNBC) lacks specific biomarkers, complicating diagnosis and prognosis.
- TNBC is defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER-2 expression.
Purpose of the Study:
- To analyze global trends and research hotspots in TNBC biomarker discovery.
- To identify areas for future research and collaboration in TNBC biomarker development.
Main Methods:
- Bibliometric analysis using CiteSpace, VOSviewer, and Scimago Graphica.
- Comprehensive literature review and keyword co-citation analysis.
Main Results:
- Rapid growth in TNBC biomarker research, with significant contributions from the US, UK, and France.
- Key research areas include immune checkpoint markers, microenvironment, circulating tumor DNA, metabolism, and genomics.
- Limited collaboration observed, highlighting a need for strengthened partnerships.
Conclusions:
- Future TNBC biomarker research will likely involve multi-omics, microenvironment studies, liquid biopsies, and AI/ML.
- Interdisciplinary collaboration and adoption of new technologies are essential for young scholars.
- Developing precise biomarkers for diagnosis, prognosis, and targeted therapy remains a key goal.
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