[Screening and functional analysis of differentially expressed long non-coding RNA in the liver of mice infected with Schistosoma japonicum during the chronic pathogenic stage]

Y Li ¹, Q Li ¹, W Lin ¹

⁰National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China.

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi = Chinese Journal of Schistosomiasis Control +

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June 10, 2024

View abstract on PubMed

Summary

This study identified 67 differentially expressed long non-coding RNAs (lncRNAs) in mice with chronic Schistosoma japonicum infection. These lncRNAs may influence liver disease development through regulating collagen and inflammatory pathways.

Area Of Science

Molecular Biology
Genomics
Parasitology

Context

Schistosoma japonicum infection causes chronic liver disease.
Long non-coding RNAs (lncRNAs) play roles in various biological processes.
Understanding lncRNA function is crucial for disease mechanism elucidation.

Purpose

To screen differentially expressed lncRNAs in the liver during chronic Schistosoma japonicum infection.
To identify the functional roles of these lncRNAs and their target genes.
To gain insights into lncRNA involvement in Schistosoma japonicum-induced liver disorders.

Summary

67 differentially expressed lncRNAs were identified in infected mouse livers (49 up-regulated, 18 down-regulated).
Target genes of these lncRNAs are involved in extracellular regulated protein kinase (ERK) cascades and collagen expression.
KEGG analysis revealed enrichment in cytokine-cytokine receptor interaction and NF-κB signaling pathways.

Impact

Identifies novel lncRNAs associated with Schistosoma japonicum-induced liver pathology.
Suggests potential therapeutic targets by highlighting lncRNA roles in inflammation and fibrosis.
Provides a foundation for further research into lncRNA-mediated mechanisms in parasitic liver diseases.

Keywords:

Extracellular regulated protein kinase Hepatic fibrosis Long non-coding RNA Mouse