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Updated: Jun 24, 2025
07:17
Non-equilibrium Microwave Plasma for Efficient High Temperature Chemistry
Published on: August 1, 2017
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Is it time for the death knell of single-unit plasma?
Richard R Gammon1, Moises Auron2,3, Deborah Tolich4
1OneBlood, Scientific, Medical, Technical Direction, Orlando, Florida, USA.
Vox Sanguinis
|June 10, 2024
Summary
More than 17% of adult patients received single-unit plasma transfusions, which is often a sub-therapeutic dose. Hospitals transfusing plasma infrequently were more likely to administer these under-dosed single-unit transfusions.
Area of Science:
- Transfusion Medicine
- Hematology
- Clinical Pathology
Background:
- Plasma transfusion dosing guidelines recommend 10-20 mL/kg, equating to 3-4 units for adults.
- Single-unit plasma transfusions are frequently sub-therapeutic and may not achieve desired clinical outcomes.
Purpose of the Study:
- To determine the prevalence of single-unit plasma transfusions in a large hospital system.
- To identify factors associated with the administration of single-unit plasma transfusions.
Main Methods:
- Retrospective observational study of adult patients receiving plasma transfusions.
- Data collected from a 12-hospital system between January 2018 and December 2019.
Main Results:
- 17.1% of 988 patients received single-unit plasma transfusions.
- Single-unit transfusions were concentrated in specific hospitals and service lines.
- Hospitals with lower plasma transfusion volumes were more likely to administer single units.
Conclusions:
- Over one in six adult patients received a single-unit plasma transfusion, indicating a potential under-dosing issue.
- Plasma transfusion practices varied significantly across hospitals and service lines within the system.
- Further investigation into transfusion practices is warranted to ensure appropriate dosing and patient care.
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