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lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

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Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
A Comprehensive Analysis Of Gas2 Family Members Identifies That Gas2l1 Is A Novel Biomarker And Promotes The Proliferation Of Hepatocellular Carcinoma.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
A Comprehensive Analysis Of Gas2 Family Members Identifies That Gas2l1 Is A Novel Biomarker And Promotes The Proliferation Of Hepatocellular Carcinoma.

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Published on: July 22, 2020

A comprehensive analysis of GAS2 family members identifies that GAS2L1 is a novel biomarker and promotes the proliferation of hepatocellular carcinoma.

Ying-Ying Xu¹, Ru-Xue Bai¹, Qing-Rui Zhang¹

¹Department of Gastroenterology, China-Japan Friendship Hospital, No. 2, Yinghua East Street, Chaoyang District, Beijing, 100029, People's Republic of China.

Discover Oncology

|June 10, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Keywords:

GAS2 family Hepatocellular carcinoma Immune cell infiltration Lipid metabolism

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Growth-arresting-specific 2 (GAS2) family members GAS2L1 and GAS2L3 are upregulated in hepatocellular carcinoma (HCC). These genes are potential prognostic markers for HCC patients and influence immune cell infiltration.

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Hepatocellular carcinoma (HCC) is a prevalent liver cancer with high mortality.
The growth-arresting-specific 2 (GAS2) gene family plays roles in human cancers, but their role in HCC is unclear.

Purpose of the Study:

To investigate the expression patterns and clinical significance of the GAS2 family in hepatocellular carcinoma.
To explore the prognostic value and potential roles of GAS2 family members in HCC development and progression.

Main Methods:

Analysis of GAS2 family gene expression in HCC and non-tumor tissues.
Pan-cancer expression analysis.
Correlation analysis with methylation levels.
Prognostic survival analysis.

Tumor microenvironment

Immune cell infiltration analysis.

In vitro experiments involving GAS2L1 knockdown in HCC cells.

Main Results:

GAS2L1 and GAS2L3 were significantly upregulated in HCC tissues compared to non-tumor tissues.
GAS2L1 and GAS2L3 demonstrated high expression across most cancer types.
GAS2, GAS2L1, and GAS2L2 expression correlated negatively with methylation levels.
GAS2L1 and GAS2L3 served as independent prognostic factors for HCC patients.
GAS2 family members were associated with various immune cells.
GAS2L1 knockdown inhibited HCC cell proliferation.

Conclusions:

GAS2L1 and GAS2L3 are promising diagnostic and prognostic biomarkers for HCC.
The GAS2 family's expression patterns and prognostic values in HCC warrant further investigation.
GAS2L1 plays a role in HCC cell proliferation.