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IGF-1's protective effect on OSAS rats' learning and memory.

Ling Zeng1, Ting Yu1, Haijun Liu1

  • 1Department of Neurology, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, Guizhou, 563000, China.

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Insulin-like growth factor-1 (IGF-1) partially reverses cognitive deficits in obstructive sleep apnea syndrome (OSAS) rats. This suggests IGF-1 may protect against OSAS-induced cognitive impairment by influencing hippocampal protein expression.

Keywords:
CognitiveIGF-1MemoryOSASSYP

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Sleep Medicine

Background:

  • Obstructive sleep apnea syndrome (OSAS) is linked to cognitive dysfunction, potentially due to chronic intermittent hypoxia (CIH).
  • The role of Insulin-like growth factor-1 (IGF-1) in OSAS-related cognitive impairment is not fully understood.
  • IGF-1 is recognized for its association with cognitive function.

Purpose of the Study:

  • To investigate the potential neuroprotective effects of IGF-1 in a rat model of OSAS.
  • To determine if IGF-1 can mitigate cognitive impairment induced by chronic intermittent hypoxia (CIH).

Main Methods:

  • A rat model of OSAS was established using chronic intermittent hypoxia (CIH) for 28 days.
  • Rats were divided into control, CIH, vehicle + CIH, and IGF-1 + CIH groups.
  • Cognitive function was assessed using the Morris water maze test, with hippocampal tissue analyzed via ELISA, H&E staining, immunohistochemistry, and Western blotting.

Main Results:

  • The OSAS rat model successfully demonstrated significant cognitive impairment.
  • Subcutaneous IGF-1 injections partially restored cognitive function in OSAS rats.
  • IGF-1, p-IGF-IR, and SYP expression levels were decreased in CIH rats but increased in the IGF-1 + CIH group.

Conclusions:

  • IGF-1 administration partially ameliorates cognitive deficits in rats with OSAS.
  • The protective effect of IGF-1 may involve the upregulation of p-IGF-1R and SYP protein in the hippocampus.
  • IGF-1 shows promise as a therapeutic agent for cognitive impairment associated with OSAS.