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The aging human brain.

H Creasey, S I Rapoport

    Annals of Neurology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Brain aging shows significant variability, with some older individuals retaining youthful brain characteristics. Despite anatomical changes, key functions like metabolism and crystallized intelligence remain intact, highlighting the brain

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    Neuroradiology·2005

    Area of Science:

    • Neuroscience
    • Gerontology
    • Human Anatomy

    Background:

    • Human brain aging involves anatomical, morphological, and neurochemical alterations.
    • Significant variability exists in aging brains, with some older brains resembling younger ones.
    • Previous research often limited by superimposed diseases affecting elderly subjects.

    Purpose of the Study:

    • To investigate the extent of functional preservation in the aging human brain.
    • To identify key cognitive and metabolic functions that remain effective in the elderly.
    • To explore the brain's inherent capabilities for maintaining function despite aging.

    Main Methods:

    • Comparative analysis of postmortem brain studies.
    • Utilized computed tomographic (CT) imaging for morphological assessment.

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  • Assessed cognitive function using verbal subtests of the Wechsler Adult Intelligence Scale.

    • Main Results:

    • Observed considerable variability in anatomical and neurochemical brain changes with age.
    • Identified preserved resting cerebral oxidative metabolism in elderly individuals.
    • Demonstrated maintained crystallized intelligence (verbal abilities) in aging subjects.

    Conclusions:

    • Aging human brains exhibit significant individual variability in structural and functional decline.
    • Key brain functions, including metabolism and crystallized intelligence, can be preserved in aging.
    • Brain plasticity and redundancy are crucial for maintaining high functional levels in the elderly, especially without disease.