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Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis

Emanuele Murgo1, Giorgia Falco1, Gaetano Serviddio2

  • 1Department of Medical Sciences, Division of Internal Medicine and Chronobiology Laboratory, Fondazione IRCCS "Casa Sollievo della Sofferenza",, Opera di Padre Pio da Pietrelcina, San Giovanni Rotondo, 71013, Italy.

Cell Communication and Signaling : CCS
|June 10, 2024
PubMed

Insights

Biological clocks regulate cell growth and differentiation. Deregulation of these clocks and growth factor signaling pathways are implicated in cancer development and progression.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • Cell proliferation and differentiation are controlled by signaling pathways initiated by ligand binding to enzyme-linked receptors.
  • These pathways involve phosphorylation events and downstream signaling, ultimately affecting gene transcription for cell growth and survival.
  • Cellular processes are regulated by intrinsic molecular clocks, and their disruption is linked to cancer.

Purpose of the Study:

  • To review the interplay between biological clocks and Growth Factor Receptor (GFR)-dependent signaling.
  • To explore the role of this interplay in carcinogenesis.

Main Methods:

  • Literature review focusing on molecular mechanisms.
  • Analysis of signaling pathways involving receptor tyrosine kinases and serine-threonine kinases.
  • Examination of the role of molecular clocks in cancer.

Main Results:

  • GFR-dependent signaling pathways are frequently dysregulated in various cancers.
  • Molecular clockworks are essential for normal cell processes and their deregulation contributes to cancer.
  • The interaction between biological clocks and GFR signaling is a critical factor in cancer initiation and progression.

Conclusions:

  • Understanding the interplay between biological clocks and GFR signaling is crucial for cancer research.
  • Targeting these pathways may offer novel therapeutic strategies for cancer treatment.
  • Further investigation into the molecular mechanisms governing this interaction is warranted.
Keywords:
Biological clockCancerCircadianGrowth factorsLigandReceptors

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