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Hyphal forms of Histoplasma capsulatum. A common manifestation of intravascular infections
Abstract:
The usual tissue form of Histoplasma capsulatum is a small intracellular yeast, though extracellular organisms of unusually large size have also been described. The production of hyphae in tissue has been regarded as rare and we believe not generally appreciated. We report a case of probable Histoplasma endocarditis from which an embolus demonstrated abundant mycelial forms on histologic examination. Of previously reported cases of H capsulatum endocarditis with detailed pathologic description, nine of 27 cases are found to demonstrate hyphal forms. Hyphal structures should be considered a common morphologic variant of H capsulatum in intravascular lesions.
Insights
Histoplasma capsulatum typically appears as yeast but can form hyphae in tissue. This study highlights that these mycelial forms are common in intravascular lesions like endocarditis.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Pathology
Background:
- Histoplasma capsulatum usually presents as intracellular yeast in tissues.
- Extracellular yeast forms, sometimes unusually large, have been documented.
- Hyphal formation in tissues is considered rare and often overlooked.