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    Area of Science:

    • Biomedical Optics
    • Optical Engineering
    • Medical Imaging

    Background:

    • Optical coherence tomography (OCT) is a valuable tool for non-invasive tissue characterization.
    • Traditional OCT systems often require bulky microscopic lenses for high-resolution imaging.
    • Characterizing tissue optical properties is crucial for disease diagnosis.

    Purpose of the Study:

    • To demonstrate a common-path OCT system utilizing a novel fiber-tip probe.
    • To characterize tissue optical properties for differentiating normal from cancerous tissues.
    • To assess the potential of the system for endoscopic or minimally invasive inspections.

    Main Methods:

    • A negative axicon structure chemically etched into a fiber tip was used as an optical probe.
    • The probe generated a Bessel beam with a large depth-of-field (∼700 µm) and small spot size (∼3 µm).
    • The OCT system imaged chicken tissue and human liver/pancreas samples without external microscopic lenses.

    Main Results:

    • The OCT system successfully obtained images of chicken tissue.
    • Refractive index and optical attenuation coefficients were estimated from the OCT data.
    • Cancerous human liver and pancreas tissues were differentiated from normal tissues based on imaging and optical properties.

    Conclusions:

    • The developed fiber-tip Bessel beam probe enables effective OCT imaging and optical property characterization.
    • The system shows promise for distinguishing cancerous from normal tissues.
    • This technology could be instrumental in early-stage malignancy detection and intraoperative assessment.