Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

New bioassay for screening immunotoxic agents.

A J Macario, E Conway de Macario

La Ricerca in Clinica E in Laboratorio

|April 1, 1979

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chaperone patterns in vernal keratoconjunctivitis are distinctive of cell and Hsp type and are modified by inflammatory stimuli.

Allergy·2015

Same author

The immunology of methanogens: a new development in microbial biotechnology.

Immunology today·2014

Same author

Antigenic fingerprinting of methanogenic bacteria with polyclonal antibody probes.

Systematic and applied microbiology·2012

Same author

Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy.

European journal of histochemistry : EJH·2012

Same author

Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells.

European journal of histochemistry : EJH·2008

Same author

Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis.

Journal of bacteriology·2004

Same journal

Increase of plasma tissue-plasminogen activator antigen levels after induced abortion.

La Ricerca in clinica e in laboratorio·1991

Same journal

Role of prostaglandin E2 on defective interferon-gamma production during type B acute viral hepatitis.

La Ricerca in clinica e in laboratorio·1991

Same journal

The use of recombinant factor VIII in the management of hemophilia.

La Ricerca in clinica e in laboratorio·1991

Same journal

The functioning liver mass.

La Ricerca in clinica e in laboratorio·1991

Same journal

Liver system. V. Activation-extinction line of cyclic hepatocyte activities.

La Ricerca in clinica e in laboratorio·1991

Same journal

Liver system. IV. More on the liver micro-unit: physics and geometry of its action.

La Ricerca in clinica e in laboratorio·1991

See all related articles

A new bioassay can assess immune system toxicity by measuring antibody response and memory development. This cost-effective method allows rapid screening of compounds for safety within 30-45 days.

Area of Science:

Immunotoxicology
Assay Development

Background:

Assessing compound toxicity to the immune system is crucial for drug development and environmental safety.
Existing methods for evaluating immunotoxicity can be time-consuming and costly.

Purpose of the Study:

To describe a novel bioassay for evaluating compounds potentially toxic to the immune system.
To enable the measurement of both enhancement and inhibition of immune responses in vivo.

Main Methods:

Utilizes immunoenzymatic techniques for high throughput.
Suitable for in vivo measurement of primary antibody response.
Allows assessment of memory development, including enhancement and inhibition.

Main Results:

The assay is adaptable for automation, reducing screening costs.

Related Experiment Videos

Provides comprehensive data on compound effects on immune memory.

Offers timely safety assessments within a 30-45 day timeframe.

Conclusions:

This bioassay offers a cost-effective, automatable, and efficient method for immunotoxicity screening.
It provides valuable insights into compound effects on adaptive immunity.
Facilitates rapid safety evaluations of potential toxicants.