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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

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Honeycomb effect elimination in differential phase fiber-bundle-based endoscopy.

Jingyi Wang, Cheng Chen, Wu You

|June 11, 2024

Summary

A new spatial pixel shifting (SPS) algorithm effectively removes the honeycomb effect in fiber-bundle endoscopy. This technique enhances real-time imaging for improved visualization of biomedical samples.

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Last Updated: Jun 24, 2025

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

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Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Published on: March 20, 2017

Area of Science:

Biomedical Imaging
Optical Engineering

Background:

Fiber-bundle endoscopy offers high resolution for in vivo imaging.
A significant challenge is the honeycomb effect, degrading image quality.

Purpose of the Study:

To develop an algorithm for suppressing the honeycomb effect in fiber-bundle endoscopy.
To enhance real-time imaging performance and image quality.

Main Methods:

An iterative-free spatial pixel shifting (SPS) algorithm was proposed.
The method involves creating shifted sub-images and computing differential maps.
Spiral integration reconstructs a honeycomb-free image.

Main Results:

Simulations and experiments validated the SPS algorithm's effectiveness.
SPS significantly improved image quality for various objects.
Enhanced visualization of reflective and transparent scattered objects was achieved.

Conclusions:

The SPS algorithm successfully suppresses the honeycomb effect.
This technique provides a foundation for advanced biomedical endoscopic applications.
Improved image quality facilitates detailed in vivo analysis.