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Allergen Sensitization of Parents and Children With Respiratory Allergic Diseases

Liping Liu1, Xuelong Li2, Yuemei Sun1

  • 1Department of Allergy, Yantai Yuhuangding Hospital, Yantai, Shandong, People's Republic of China.

Indian Pediatrics
|June 11, 2024
PubMed

Insights

Children show higher sensitivity to fungal and food allergens than their parents. Parental sensitivity to tree and weed pollen increases offspring risk for these allergies.

Area of Science:

  • Allergy and Immunology
  • Pediatrics
  • Genetics

Background:

  • Respiratory allergic diseases like asthma and rhinitis affect numerous children and adults.
  • Understanding familial patterns of allergen sensitization is crucial for diagnosis and prevention.
  • Parent-offspring comparisons can reveal genetic and environmental influences on allergic conditions.

Purpose of the Study:

  • To investigate differences in allergen sensitization between parents and their children diagnosed with respiratory allergies.
  • To identify specific allergens where sensitization patterns differ between generations.
  • To explore potential parental allergen exposure risks for offspring sensitization.

Main Methods:

  • A cohort of parent-child dyads with allergic asthma and/or allergic rhinitis was studied.
  • Allergen-specific immunoglobulin E (sIgE) levels were measured for six allergen categories.
  • Data on demographics, feeding history, total IgE, and absolute eosinophil counts were analyzed.

Main Results:

  • Children exhibited significantly higher absolute eosinophil counts than parents.
  • Children showed significantly greater sensitivity to fungal allergens compared to both mothers and fathers.
  • Children had higher food allergen sensitivity than fathers, and parental pollen sensitivity correlated with offspring sensitization.

Conclusions:

  • Children display heightened sensitization to fungal and food allergens compared to their parents.
  • Parental sensitivity to tree and weed pollen is a risk factor for similar sensitivities in their children.
  • These findings highlight generational differences in allergen responses and familial risk factors.
Abstract

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