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ROR1-AS1: A Meaningful Long Noncoding RNA in Oncogenesis
Hong Fan1,2,3, Yunxi Zhou1,2,3, Ziyan Zhang1,2,3
1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, China.
Long noncoding RNA (lncRNA) ROR1-AS1 is implicated in various cancers. Its abnormal expression affects tumor growth and spread, making it a potential therapeutic target and biomarker for multiple malignancies.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long noncoding RNAs (lncRNAs) are regulatory molecules involved in human diseases.
- Aberrant lncRNA expression is linked to tumorigenesis.
- Antisense lncRNAs, like ROR1-AS1, play roles in various cancers.
Purpose of the Study:
- To review the pathophysiology and molecular mechanisms of ROR1-AS1 in malignancies.
- To explore ROR1-AS1 as a potential biomarker and therapeutic target in cancer.
Main Methods:
- Literature retrieval on ROR1-AS1 in human malignancies.
- Analysis of ROR1-AS1's role in cancer cell proliferation, migration, invasion, and apoptosis.
- Investigation of ROR1-AS1's regulatory interactions with ROR1 and microRNAs.
Main Results:
- ROR1-AS1 is abnormally expressed (over- or underexpressed) in liver cancer, colon cancer, osteosarcoma, glioma, cervical cancer, bladder cancer, lung adenocarcinoma, and mantle cell lymphoma.
- ROR1-AS1 promotes cancer cell proliferation, migration, invasion, and inhibits apoptosis.
- ROR1-AS1 influences tumor development by modulating ROR1 conjugates and specific microRNAs (e.g., miR-504, miR-4686, miR-670-3p, miR-375).
Conclusions:
- ROR1-AS1 is a cancer-associated lncRNA with significant roles in tumorigenesis across multiple cancer types.
- ROR1-AS1's involvement in key cancer processes suggests its potential as a diagnostic marker and therapeutic target.
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