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Correlation between fat-soluble vitamin levels and inflammatory factors in paediatric community-acquired pneumonia: A

Jianyuan Liao1, Lifang Zhang2, Gangxin Chen3

  • 1Department of Blood Transfusion, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Open Medicine (Warsaw, Poland)
|June 11, 2024
PubMed

Insights

Children with community-acquired pneumonia (CAP) have lower levels of vitamins A, D, and E. These vitamin levels correlate with inflammatory markers, suggesting a role in CAP development and progression.

Area of Science:

  • Pediatrics
  • Immunology
  • Nutritional Science

Background:

  • Community-acquired pneumonia (CAP) is a significant respiratory illness in pediatric populations.
  • Understanding the interplay between nutritional status and inflammatory responses in CAP is crucial for effective management.

Purpose of the Study:

  • To investigate the association between serum levels of fat-soluble vitamins (A, D, E) and key inflammatory markers in children diagnosed with CAP.
  • To explore potential correlations between vitamin deficiencies and specific inflammatory mediators in pediatric CAP.

Main Methods:

  • A prospective cohort study involving 110 children with CAP and 100 healthy controls.
  • Measurement of serum vitamin A, D, E levels and inflammatory markers including tumor necrosis factor-alpha (TNF-a), interleukin-1 (IL-1), interleukin-10 (IL-10), neutrophils (NE), and C-reactive protein (CRP).
  • Statistical analysis including comparison between groups and Pearson correlation to assess relationships.

Main Results:

  • Children with CAP exhibited significantly lower levels of vitamins A, D, and E compared to healthy controls.
  • Elevated levels of TNF-a and IL-1 were observed in the CAP group, whereas IL-10 levels did not show significant differences.
  • Significant correlations were found between vitamin A, D, E levels and inflammatory markers like TNF-a, IL-10, and CRP.

Conclusions:

  • Reduced levels of fat-soluble vitamins A, D, and E are associated with pediatric community-acquired pneumonia.
  • These vitamin levels demonstrate a correlation with specific inflammatory markers, suggesting a potential role in the pathogenesis of CAP.
  • Findings may inform novel strategies for the prevention, diagnosis, and treatment of CAP in children.

Keywords:
IL-1IL-10TNF-afat-soluble vitaminspaediatric CAP

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