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Ceftriaxone-induced symptomatic cholelithiasis in a child: case report and literature review

Mohammad I Smerat1, Balqis Shawer2, Bara M AbuIrayyeh2

  • 1Radiology Department, Ahli Hospital, Palestine.

Oxford Medical Case Reports
|June 11, 2024
PubMed

Insights

Ceftriaxone, a common antibiotic, can rarely cause gallbladder inflammation (cholecystitis) in children. Stopping the drug promptly resolved the condition in an 8-year-old patient.

Area of Science:

  • Pediatric Pharmacology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Ceftriaxone is a widely used third-generation cephalosporin antibiotic in pediatric care due to its broad spectrum and safety.
  • Uncommon adverse events, including cholecystitis (gallbladder inflammation), have been associated with ceftriaxone therapy.

Observation:

  • An 8-year-old female patient presented with right upper quadrant pain and nausea.
  • Imaging revealed gallstones and sludge, indicative of acute cholecystitis during ceftriaxone treatment.

Findings:

  • Discontinuation of ceftriaxone and supportive care led to the resolution of cholecystitis.
  • Gallbladder sludge and stones resolved completely following antibiotic withdrawal.

Implications:

  • Highlights the importance of recognizing ceftriaxone-induced cholecystitis in pediatric patients.
  • Early identification and cessation of the antibiotic can prevent surgical intervention and ensure successful treatment outcomes.

Keywords:
ceftriaxonecholecystitischolecystolithiasisdrug-induced

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