Survival benefits of gastrectomy in patients with metastatic gastric cancer: A meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Gastrectomy significantly improves survival for metastatic gastric cancer (MGC) patients compared to non-resection. This surgical approach offers better overall survival (OS) and a reduced risk of death, with no increase in postoperative complications.
Area Of Science
- Oncology
- Surgical Oncology
- Gastroenterology
Background
- Metastatic gastric cancer (MGC) presents a poor prognosis with limited curative options.
- Surgical resection is the only treatment offering potential cure, but its role remains debated.
Purpose Of The Study
- To evaluate the impact of gastrectomy versus non-resection on survival outcomes in MGC patients.
- To assess the role of surgical intervention in improving the prognosis of MGC.
Main Methods
- A systematic review and meta-analysis of studies comparing gastrectomy with non-resection for MGC.
- Searched PubMed, Embase, Cochrane Library, and Web of Science databases up to October 2023.
- Primary outcomes included 1-, 2-, 3-, and 5-year overall survival (OS) and OS time.
Main Results
- Forty-six studies involving 7,152 MGC patients were analyzed.
- Gastrectomy significantly improved 1-, 2-, 3-, and 5-year OS and reduced the risk of death compared to non-resection.
- No significant difference in postoperative morbidity was observed between groups.
Conclusions
- Gastrectomy, with or without metastasectomy, offers survival benefits for MGC patients.
- Surgical intervention should be considered for select MGC patients to improve outcomes.
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