Related Experiment Video

Updated: May 6, 2026

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

12.2K

Complete genome sequence of Parvimonas micra strain JM503A, a genetically tractable dental abscess clinical isolate

Dustin L Higashi1, Anh Nguyen2, Hua Qin1

  • 1Division of Biomaterial and Biomedical Sciences, Oregon Health and Science University, Portland, Oregon, USA.

Microbiology Resource Announcements
|June 11, 2024
PubMed

Insights

Parvimonas micra, a pathobiont linked to inflammation and tumors, has had its complete genome sequenced. This genetic information from a clinical isolate aids future research into this opportunistic human bacterium.

Area of Science:

  • Microbiology
  • Genomics
  • Human Pathobionts

Background:

  • Parvimonas micra is recognized as a pathobiont in humans.
  • This bacterium frequently colonizes sites of mucosal inflammation and malignant tumors.
  • Its role in disease pathogenesis is an area of ongoing investigation.

Purpose of the Study:

  • To report the complete genome sequence of Parvimonas micra strain JM503A.
  • To provide a valuable genomic resource for studying P. micra.
  • To facilitate research into the pathobiont's role in human diseases.

Main Methods:

  • Isolation of Parvimonas micra strain JM503A from a human odontogenic abscess.
  • Whole-genome sequencing of the clinical isolate.
  • Bioinformatic analysis of the obtained genome sequence.

Main Results:

  • The complete genome sequence of Parvimonas micra strain JM503A has been successfully determined.
  • Strain JM503A is a genetically tractable clinical isolate.
  • The genome sequence provides a foundation for understanding P. micra's biology and pathogenicity.

Conclusions:

  • The availability of the P. micra JM503A genome sequence enhances our understanding of this pathobiont.
  • This genomic data is crucial for future studies on P. micra's involvement in inflammatory conditions and cancer.
  • The genetically tractable nature of the isolate opens avenues for experimental research.
Keywords:
Parvimonas micragenome

More Related Videos

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies12:08

Hybrid De Novo Genome Assembly for the Generation of Complete Genomes of Urinary Bacteria using Short- and Long-read Sequencing Technologies

Published on: August 20, 2021

5.0K
Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing09:44

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

2.2K

Related Concept Videos

Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
42.5K
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
1.5K
Diversity of Protists I01:15

Diversity of Protists I

Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
2.3K
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
115