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Smart Cancer Nanomedicine for Synergetic Therapy
Anwesha Kanungo1, Chandana Mohanty1, Sarbari Acharya1
1School of Applied Sciences, Kalinga Institute of Industrial Technology, Bhubaneswar, 751024, Odisha, India.
Abstract:
Cancer is the second leading cause of death. Notwithstanding endeavors to comprehend tumor causes and therapeutic modalities, no noteworthy advancements in cancer therapy have been identified. Nanomedicine has drawn interest for its diagnostic potential because of its ability to deliver therapeutic agents specifically to tumors with little adverse effects. Nanomedicines have become prevalent in the treatment of cancer. Here, we present four strategic suggestions for improvement in the functionality and use of nanomedicine. (1) Smart drug selection is a prerequisite for both medicinal and commercial achievement. Allocating resources to the advancement of modular (pro)drugs and nanocarrier design ought to consider the role of opportunistic decisions depending on drug availability. (2) Stimuli-responsive nanomedicine for cancer therapy is being designed to release medications at particular locations precisely. (3) The cornerstone of clinical cancer treatment is combination therapy. Nanomedicines should be included more frequently in multimodal combination therapy regimens since they complement pharmacological and physical co-treatments. (4) Regulation by the immune system is transforming cancer therapy. Nanomedicines can improve the effectiveness of the immune system and control the behavior of anticancer immunity. These four approaches, both separately and particularly in combination, will accelerate and promote the creation of effective cancer nanomedicine treatments.
Insights
Nanomedicine offers targeted cancer treatment with minimal side effects. Strategic improvements in smart drug selection, stimuli-responsive systems, combination therapies, and immune system regulation can enhance nanomedicine
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Cancer remains a leading cause of death with limited therapeutic advancements.
- Nanomedicine shows promise for targeted cancer diagnosis and treatment, minimizing adverse effects.
- Current nanomedicine applications in cancer therapy are expanding.
Purpose of the Study:
- To propose four strategic recommendations for enhancing nanomedicine functionality and application in cancer therapy.
- To highlight the potential of nanomedicine in improving cancer treatment outcomes.
- To accelerate the development of effective nanomedicine-based cancer treatments.
Main Methods:
- Strategic suggestion 1: Emphasize smart drug selection and nanocarrier design, considering drug availability.
- Strategic suggestion 2: Develop stimuli-responsive nanomedicine for precise drug release at tumor sites.
- Strategic suggestion 3: Integrate nanomedicines into multimodal combination therapy regimens.
- Strategic suggestion 4: Leverage nanomedicines to modulate the immune system for enhanced anticancer immunity.
Main Results:
- Smart drug selection optimizes both therapeutic and commercial success.
- Stimuli-responsive nanomedicines enable targeted drug delivery.
- Combination therapy incorporating nanomedicines complements existing treatments.
- Nanomedicines can enhance immune system effectiveness against cancer.
Conclusions:
- Implementing these four strategies, individually or combined, will significantly advance cancer nanomedicine.
- These approaches promise to accelerate the creation of more effective nanomedicine treatments for cancer.
- Nanomedicine holds substantial potential to revolutionize cancer therapy through targeted delivery and immune modulation.
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