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Protocol for detecting micro(nano)plastics released from intravenous infusion products
Penghui Li1, Qingcun Li2, Yujian Lai3
1School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Detecting micro(nano)plastics from medical infusions is crucial for health safety. This study details a protocol using Raman spectroscopy, SEM-EDS, and Py-GC-MS to identify polyvinyl chloride micro(nano)plastics.
Area of Science:
- Environmental Science
- Analytical Chemistry
- Materials Science
Background:
- Micro(nano)plastics (MNPs) contamination is a growing concern, particularly in medical applications.
- Intravenous infusion products (IVIPs) are a potential source of MNPs exposure.
- Assessing the health risks associated with MNPs from IVIPs requires reliable detection methods.
Purpose of the Study:
- To present a comprehensive protocol for the detection of polyvinyl chloride (PVC) MNPs.
- To establish a method for quantifying MNPs released from intravenous infusion products (IVIPs).
- To provide a foundation for evaluating the safety of IVIPs and associated MNPs.
Main Methods:
- Development of a multi-analytical protocol combining Raman spectroscopy, scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), and pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS).
- Detailed procedures for sample collection, pretreatment, and measurement of PVC MNPs.
- Application of the protocol to detect MNPs released from IVIPs.
Main Results:
- Successful implementation of a protocol for detecting PVC MNPs in IVIPs.
- Demonstration of a combined analytical approach for robust MNP identification and characterization.
- Quantification of MNPs released from specific IVIPs.
Conclusions:
- The presented protocol offers a reliable method for detecting PVC MNPs from IVIPs.
- This approach is vital for assessing the safety of medical products and understanding MNP health impacts.
- Further research can build upon this protocol to investigate other MNP types and sources.
