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The multifaceted role of SOX2 in breast and lung cancer dynamics

Kiavash Hushmandi1, Seyed Hassan Saadat1, Seyedalireza Mirilavasani2

  • 1Nephrology and Urology Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, the Islamic Republic of Iran.

Pathology, Research and Practice
|June 11, 2024
PubMed

Insights

SOX2 protein imbalance drives breast and lung cancer growth, metastasis, and treatment resistance. Targeting SOX2 may enhance therapeutic effectiveness against these deadly diseases.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Breast and lung cancers are major global health threats with increasing mortality.
  • Conventional treatments face challenges due to treatment resistance and disease progression.
  • Molecular interactions, including SOX2 expression, significantly influence cancer development.

Purpose of the Study:

  • To review the multifaceted role of SOX2 in breast and lung cancer.
  • To elucidate how SOX2 dysregulation impacts cancer progression and therapeutic outcomes.
  • To explore SOX2's influence on cell death, metastasis, and treatment resistance.

Main Methods:

  • Literature review of studies investigating SOX2 in breast and lung cancer.
  • Analysis of SOX2's molecular functions and regulatory mechanisms.
  • Examination of SOX2's impact on cancer hallmarks like proliferation, apoptosis, and epithelial-to-mesenchymal transition (EMT).

Main Results:

  • Aberrant SOX2 expression promotes tumor growth, metastasis via EMT, and resistance to chemotherapy and radiation.
  • SOX2 can inhibit programmed cell death pathways, including autophagy.
  • Genetic and epigenetic factors contribute to altered SOX2 levels in cancer.

Conclusions:

  • SOX2 is a critical factor in breast and lung cancer pathogenesis.
  • Modulating SOX2 offers a potential therapeutic strategy to overcome treatment resistance.
  • Targeting SOX2 may improve treatment efficacy for patients with breast and lung cancers.
Keywords:
Breast cancerChemoresistanceLung cancerNon-coding RNAsSOX2

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