Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Hepatic circulation in cirrhosis.

P M Huet, J P Villeneuve, G Pomier-Layrargues

Clinics in Gastroenterology

|January 1, 1985

Summary

Liver cirrhosis impairs blood-liver exchange through microvascular changes like capillarization and shunts. These alterations, not just reduced cell mass, hinder substrate uptake and liver function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Comparison of Microbial Sulfuric Acid Production in Sewage Sludge from Added Sulfur and Thiosulfate.

Journal of environmental quality·2021

Same author

Effect of natural dissolved organic matter found in groundwater on soil adsorption and transport of pentachlorophenol.

Environmental science & technology·2011

Same author

Predictive factors of bleeding related to post-banding ulcer following endoscopic variceal ligation in cirrhotic patients: a case-control study.

Alimentary pharmacology & therapeutics·2010

Same author

Improved survival after liver transplantation in patients with hepatopulmonary syndrome.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2009

Same author

Agrochemical and polychlorobyphenyl (PCB) residues in the Mekong River delta, Vietnam.

Marine pollution bulletin·2008

Same author

Survival after liver transplantation for hepatitis C is unchanged over two decades in Canada.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2008

Area of Science:

Hepatology
Vascular Biology
Physiology

Background:

Cirrhosis leads to liver dysfunction, often attributed to reduced liver cell mass or function.
Microvascular changes in cirrhotic livers, including capillarization and intrahepatic shunts, are recognized but their functional impact requires further elucidation.

Purpose of the Study:

To characterize microvascular alterations in cirrhotic livers using the multiple indicator dilution technique.
To investigate the contribution of capillarization and intrahepatic shunts to impaired blood-liver exchange and substrate uptake in cirrhosis.

Main Methods:

Utilized the multiple indicator dilution approach to assess microvascular events in the liver.
Analyzed anatomical alterations, specifically capillarization and intrahepatic shunts, in cirrhotic livers.

Main Results:

Identified capillarization and intrahepatic shunts as key anatomical alterations in cirrhotic livers.
Demonstrated that the combination of capillarization and shunts progressively limits blood-liver exchange.
Provided evidence that abnormal hepatic substrate uptake, due to these vascular changes, contributes to impaired liver function in cirrhosis.

Conclusions:

Capillarization of hepatic sinusoids significantly impacts substrate elimination in cirrhosis.
Intrahepatic shunts exacerbate the functional deficits caused by capillarization, further compromising liver function.

Related Experiment Videos