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Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
658

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Related Experiment Video

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Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase
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Creating elastase aneurysms in rabbits: a video primer.

Jonathan Cortese1,2,3, Esref Alperen Bayraktar4, Alexander A Oliver4

  • 1Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA cortese.jonathan@mayo.edu.

Journal of Neurointerventional Surgery
|June 11, 2024
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Summary

This study details a reproducible elastase-induced rabbit carotid artery aneurysm model. This pre-clinical tool aids in evaluating neuroendovascular devices and understanding aneurysm healing processes.

Keywords:
Aneurysm

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Area of Science:

  • Vascular Surgery
  • Pre-clinical Research
  • Neuroendovascular Devices

Background:

  • The New Zealand rabbit elastase-induced arterial aneurysm model is crucial for evaluating neuroendovascular devices.
  • This model mimics human intracranial aneurysms in morphology, hemodynamics, and histology.
  • Understanding aneurysm healing post-endovascular treatment requires reliable in vivo models.

Purpose of the Study:

  • To provide a detailed procedural guide for creating elastase-induced aneurysms in rabbits.
  • To ensure reproducibility and minimize animal use in pre-clinical aneurysm research.
  • To promote the use of this validated animal model for neuroendovascular device assessment.

Main Methods:

  • Utilized open and endovascular surgical techniques for aneurysm creation.
  • Emphasized meticulous procedural steps for reproducibility.
  • Presented a step-by-step video guide for aneurysm creation and follow-up.

Main Results:

  • The elastase-induced aneurysm model in New Zealand rabbits demonstrates key characteristics of human intracranial aneurysms.
  • The procedural guide ensures a reproducible method for aneurysm creation.
  • The model facilitates in vivo investigations of aneurysm healing.

Conclusions:

  • The elastase-induced rabbit carotid artery aneurysm model is a valuable tool for pre-clinical research.
  • This procedural guide enhances the reliability and promotes the adoption of this model.
  • Further research utilizing this model can advance neuroendovascular device development and aneurysm treatment strategies.